Dr. David Huang, MD, PhD
Current Positions
- Director of Doheny Laser Vision Center
- Charles C. Manger Chair in Corneal Laser Surgery
- Associate Professor of Ophthalmology & Biomedical Engineering, USC
- Director, Center for Ophthalmic Optics & Lasers
- Chairman, Advanced Imaging for Glaucoma Study
Education/Training
- MD: Harvard Medical School
- PhD in Medical Engineering & Medical Physics: Massachusetts Institute of Technology
- Ophthalmology Residency: University of Southern California / Doheny Eye Institute
- Fellowship in Cornea, External Diseases and Refractive Surgery: Emory University
Certification
Procedures Performed
- iLASIK all-laser LASIK
- CustomVue wavefront-guided laser treament
- Cataract surgery with astigmatism or presbyopia correcting lens implant
- IEK femtosecond laser enabled corneal transplantation
- Intacs intracorneal ring segment implants
- Verisyse phakic intraocular lens implantation
- AK astigmatic keratotomy/corneal relaxing incisions
Invention
Dr. David Huang, MD coinvented optical coherence tomography (OCT), a technique for imaging and measuring internal eye structures with microscopic precision.
PATENTS
1. EA Swanson, D Huang, JG Fujimoto, CA Puliafito, CP Lin, JS Schuman. “Methods and apparatus for optical imaging with means for controlling the longitudinal range of the sample.” U.S. patent No. 5,321,501, issued June 14, 1994
2. RC Lee, D Huang, “Method for producing oriented connective tissue cells in a ligament configuration.” U.S. patent No. 5,521,087, issued May 28, 1996
3. RC Lee, D Huang, “Method for producing oriented connective tissue cells.” U.S. patent No. 5,700,688, issued December 23, 1997
4. RC Lee, D Huang, “Method for producing oriented connective tissue.” U.S. patent No. 5,756,350, issued May 26, 1998
5. D Huang, PJ McDonnell, "Apparatus and method for performing laser thermal keratoplasty with minimized regression" U.S. patent No. 6,033,396, issued March 7, 2000, expires November 6, 2016
6. J Wei, D Huang, C Peterson, “Optical coherence tomography with new interferometer” U.S. Patent No. 6,053,613, issued April 25, 2000 7. D Huang, AR Kirschbaum, J Wei, “Method and apparatus for diagnosing and monitoring eye disease” U.S. Patent No. 6,293,674, issued September 25, 2001
8. D Huang, “Apparatus and methods for performing laser thermal keratoplasty with minimized regression” U.S. patent No. 6,520,956, issued February 18, 2003, expires November 6, 2016
9. D Huang, O Tan, Y Li, “Method and apparatus for measuring a retinal sublayer characteristic” U.S. patent No. 7,347,548, issued March 25, 2008, expires May 2023.
10. D Huang, M Tang, "Gaussian fitting on mean curvature maps for parameterization of corneal ectatic diseases" U.S. patent application serial number 11/743,136 filed May 23, 2007; U.S. patent No. 7,497,575 issued March 3, 2009.
Awards
2004 Achievement Award from the American Academy of Ophthalmology
2007 Charles C. Manger III, MD Chair in Corneal Laser Surgery
Publications
PEER REVIEWED JOURNAL ARTICLES
1. Huang D, Wang J, Lin CP, Puliafito CA, Fujimoto JG. Micron-resolution ranging of cornea and anterior chamber by optical reflectometry." Lasers in Surgery and Medicine 1991;11: 419-25
2. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K., Puliafito CA, Fujimoto JG. Optical coherence tomography. Science 1991;254:1178-81.
3. Gabetta G, Huang , Jacobson J, Ramaswamy M, Ippen EP, Fujimoto JG. Femtosecond pulse generation in Ti:Al2O3 using a microdot mirror modelocker. Optics Letters 1991;16:1756-8.
4. Swanson EA, Huang D, Hee MR, Fujimoto JG, Lin CP, Puliafito CA. High-speed optical coherence domain reflectometry. Optics Letters 1992;17;151-3.
5. Huang D, Ulman M, Acioli LH, Haus HA, Fujimoto JG. Self-focusing induced saturable loss for laser modelocking. Optics Letters 1992;17:511-3.
6. Hee MR, Huang D, Swanson EA, Fujimoto JG. Polarization sensitive low coherence reflectometer for birefringence characterization and ranging. Journal of the Optical Society of America B: Optical Physics 1992;9:903-8.
7. Weiss TF, Trevisan G, Doering EB, Shah DM, Huang D, Berkenblit SI. “Software for teaching physiology and biophysics,” Journal of Science Education and Technology 1992;1:4-23.
8. Huang D, Chang TR, Aggarwal A, Lee RC, Ehrlich HP. Mechanisms and dynamics of mechanical strengthening in ligament-equivalent fibroblast-populated collagen matrices. Annals of Biomedical Engineering 1993;21:289-98.
9. Swanson EA, Izatt JA, Hee MR, Huang D, Lin CP, Schuman JS, Puliafito CA, Fujimoto JG. In vivo retinal imaging by optical coherence tomography Optics Letters 1993;18:1864-6.
10. Izatt JA, Hee MR, Swanson EA, Lin CP, Huang D, Schuman JS, Puliafito CA, Fujimoto JG. Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. Archives of Ophthalmology 1994;112:1584-9.
11. Hee MR, Izatt JA, Swanson EA, Huang D, Schuman JS, Lin CP, Puliafito CA, Fujimoto JG. Optical coherence tomography of the human retina. Archive of Ophthalmology 1995;113:325-32.
12. Huang D, Stulting RD, Carr JD, Thompson KP, Waring GO III. Multiple regression and vector analyses of refractive outcomes of laser in-situ keratomileusis for myopia and astigmatism. Journal of Refractive Surgery 1999;15:538-49.
13. Huang D, Sur S, Seffo F, Meisler D, Krueger RR. Surgically-Induced Astigmatism Associated with Spherical Laser in-situ Keratomeileusis for Myopia. Journal of Refractive Surgery 2000;16(5):515-18.
14. Jeng BH, Huang D. Anterior chamber stability during bimanual irrigation/aspiration: theoretical and experimental analysis. Journal of Cataract & Refractive Surgery 2001;27:1670-8.
15. Rapuano CJ, Sugar A, Koch DD, Agapitos PJ, Culbertson WW, de Louise VP, Huang D, Varley GA. Intrastromal corneal ring segments for low myopia: a report by the American Academy of Ophthalmology. Ophthalmology 2001;108(10): 1922-8.
16. Pineda-Fernandez A, Rueda L, Huang D, Nur J, Jarmillo J. Laser in situ keratomileusis for hyperopia and hyperopic astigmatism with the Nidek EC-5000 excimer laser. Journal of Refractive Surgery 2001;17(6):670-675.
17. Sugar A, Rapuano CJ, Culbertson WW, Huang D, Varley GA, Agapitos PJ, de Louise VP, Koch DD. Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy; a report by the American Academy of Opthalmology. Ophthalmology 2002; 109(1):175-187.
18. Huang D, Arif M, Spot Size and Quality of Scanning Laser Correction of Higher Order Wavefront Aberrations. Journal of Cataract & Refractive Surgery 2002;28(3):407-416.
19. Rueda L, Pineda-Fernandez A, Huang D, Nur J. Laser in situ keratomileusus for mixed and simple myopic astigmatism with the Nidek EC-5000 laser. Journal of Refractive Surgery 2002;18(3):234-238.
20. Tekwani N, Huang D. Risk Factors for Microkeratome-Related Epithelial Defect. American Journal of Ophthalmology 2002;134(3):311-16.
21. Huang D, Tang M, Shekhar R. Mathematical Model of Corneal Surface Smoothing after Laser Refractive Surgery. American Journal of Ophthalmology, 2003; 135(3):267-278.
22. Garcia ML, Huang D, Crowe S, Traboulsi EI. Relationship between the axis and degree of high astigmatism and obliquity of palpebral fissure. Journal of American Association for Pediatric Ophthalmology and Strabismus (AAPOS), 2003; 7(1):14-22.
23. Lin RC, Shure MA, Rollins AM, Izatt JA. Huang D. Group index of human cornea at 1.3 µm wavelength obtained in vitro by optical coherence domain reflectometry. Optics Letters, 2003; 29(1):83-85.
24. Varley GA, Huang D, Rapuano CJ, Schallhorn S, Boxer Wachler BS, Sugar A. LASIK for hyperopia, hyperopic astigmatism, and mixed astigmatism: a report by the American Academy of Ophthalmology. Ophthalmology 2004; 111(8):1604-1617.
25. Jeon SW, Shure MA, Rollins AM, Huang D. Corneal hydration imaging using dual-wavelength optical coherence tomography. Proceedings of SPIE 2004; 5316:113-118.
26. Huang D, Li Y, Radhakrishnan S, Optical coherence tomography of the anterior segment of the eye. Ophthalmology Clinic of North America 2004; 17(1):1-6.
27. Goldsmith JA, Li Y, Chalita MR, Westphal V, Patil CA, Rollins AM, Izatt JA, Huang D. Anterior chamber width measurement by high-speed optical coherence tomography. Ophthalmology 2005; 112(2):238-244.
28. Tang M, Shekhar R, Huang D, Mean curvature mapping for the detection of corneal shape abnormality. IEEE Transaction on Medical Imaging 2005; 24(3): 424-427.
29. Thorell WE, Chow MM, Prayson RA, Shure MA, Jeon SW, Huang D, Zeynalov E, Woo HH, Rasmussen PA, Masaryk TJ, Optical coherence tomography: a new method to assess aneurysm healing. Journal of Neurosurgery 2005; 102:348-354.
30. Radhakrishnan S, Goldsmith J, Huang D, Westphal V, Dueker DK, Rollins AM, Izatt JA, Smith SD. Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles. Archive of Ophthalmology 2005; 123:1053-1059.
31. Radhakrishnan S, Huang D, Smith SD. Optical coherence tomography imaging of the anterior chamber angle. Ophthalmology Clinics of North America 2005; 18(3):375-381.
32. Tang M, Shekhar R, Miranda D, Huang D. Characteristics of keratoconus on mean curvature and elevation maps. American Journal of Ophthalmology 2005; 140(6):993-1001.
33. Chalita, MR, Li Y, Smith S, Patil C, Westphal V, Rollins AM, Izatt JA, Huang D. High-speed optical coherence tomography of laser iridotomy. American Journal of Ophthalmology 2005; 140(6):1133-1136.
34. Jeon SW, Shure MA, Baker KB, Chahlavi A, Hatoum N, Turbay M, Rollins AM, Huang D. Optical Coherence Tomography and Optical Coherence Domain Reflectometry for Deep Brain Stimulation probe guidance. Proceedings of SPIE 2005; 5686:487-494.
35. Jeon SW, Shure MA, Baker KB, Huang D, Rollins, AM, Chahlavi A, and Rezai AR, A feasibility study of optical coherence tomography for guiding deep brain probes. J Neurosci Methods 2006; 154(1-2):96-101.
36. Li Y, Shekhar R, Huang D, Corneal pachymetry mapping with high-speed optical coherence tomography, Ophthalmology 2006; 113(5):792-799.
37. Sadda SR, Tan O, Walsh AC, Schuman JS, Varma R, Huang D, Automated detection of clinically significant macular edema by grid scanning optical coherence tomography, Ophthalmology 2006; 113(7):1187-1196.
38. Torres LF, Saez-Espinola F, Colina JM, Retchkiman M, Patel MR, Agurto R, Garcia G, Diaz JL, Huang D, Schanzlin DJ, Chayet AS. In vivo architectural analysis of 3.2 mm clear corneal incisions for phacoemulsification using optical coherence tomography. Journal of Cataract & Refractive Surgery 2006; 32(11): 1820-1826.
39. Avila M, Li Y, Song JC, Huang D. High-speed optical coherence tomography for post-LASIK management. Journal of Cataract & Refractive Surgery 2006; 32(11): 1836-1842.
40. Tang M, Li Y, Avila M, Huang D. Measurement of total corneal power before and after LASIK with high-speed optical coherence tomography. Journal of Cataract & Refractive Surgery 2006; 32(11):1843-1850.
41. Lai MM, Tang M, Andrade EMM, Li Y, Khurana RN, Song JC, Huang D. Optical coherence tomography to assess intrastromal corneal ring segment depth in keratoconic eyes. J Cataract Refract Surg 2006;32:1860-5.
42. Costa RA, Skaf M, Melo LA, Calucci D, Cardillo JA, Castro JC, Huang D, Wojtkowski M. Retinal assessment using optical coherence tomography. Prog Retin Eye Res 2006;25:325-53.
43. Sehi M, Guaqueta DC, Feuer WJ, Greenfield DS; Advanced Imaging in Glaucoma Study Group. Scanning laser polarimetry with variable and enhanced corneal compensation in normal and glaucomatous eyes. Am J Ophthalmol 2007;143:272-9.
44. Bakri SJ, Singh AD, Lowder CY, Chalita MR, Li Y, Izatt JA, Rollins AM, Huang D. Imaging of iris lesions with high-speed optical coherence tomography. Ophthalmic Surg Lasers Imaging 2007;38:27-34.
45. Pedersen CJ, Huang D, Shure MA, Rollins AM. Measurement of absolute flow velocity vector using dual-angle delay-encoded Doppler optical coherence tomography. Opt Lett 2007;32:506-8.
46. Lin RC, Li Y, Tang M, McLain M, Rollins AM, Izatt JA, Huang D. Screening for previous refractive surgery in eye bank corneas using optical coherence tomography. Cornea 2007;26:594-9.
47. Li Y, Netto MV, Shekhar R, Krueger RR, Huang D. A longitudinal study of LASIK flap and stromal thickness with high-speed optical coherence tomography. Ophthalmology 2007;114:1124-32.
48. Khurana RN, Li Y, Tang M, Lai MM, Huang D. High-speed optical coherence tomography of corneal opacities. Ophthalmology 2007;114:1278-85.
49. Memarzadeh F, Li Y, Francis BA, Smith RE, Gutmark J, Huang D. Optical coherence tomography of the anterior segment in secondary glaucoma with corneal opacity after penetrating keratoplasty. Br J Ophthalmol 2007;91:189-92.
50. Memarzadeh F, Li Y, Chopra V, Varma R, Francis BA, Huang D. Anterior segment optical coherence tomography for imaging the anterior chamber after laser peripheral iridotomy. Am J Ophthalmol 2007;143877-9.
51. Radhakrishnan S, See J, Smith SD, Nolan WP, Ce Z, Friedman DS, Huang D, Li Y, Aung T, Chew PTK. Reproducibility of anterior chamber angle measurements obtained with anterior segment optical coherence tomography. Invest Ophthalmol Vis Sci 2007;48:3683-8.
52. Reddy HS, Li Y, Yiu SC, Irvine JA, Huang D. Optical coherence tomography of corneal and scleral melts. Ophthalmic Surg Lasers Imaging 2007;38:514-7. 53. Wang Y, Bower BA, Izatt JA, Tan O, Huang D. In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography. J Biomed Opt 2007;12:041215-22.
54. See JL, Chew PT, Smith SD, Nolan WP, Chan YH, Huang D, Zheng C, Foster PJ, Aung T, Friedman DS. Changes in anterior segment morphology in response to illumination and after laser iridotomy in Asian eyes: an anterior segment OCT study. Br J Ophthalmol 2007;91:1485-9.
55. Tan O, Li G, Lu ATH, Varma R, Huang D; Advanced Imaging for Glaucoma Study Group. Mapping of macular substructures with optical coherence tomography for glaucoma diagnosis. Ophthalmology 2008;115:949-56.
56. Su DHW, Friedman DS, See JLS, Chew PTK, Chan YH, Nolan WP, Smith SD, Huang D, Zheng C, Li Y, Foster, PJ, Aung T. Degree of angle closure and extent of peripheral anterior synechiae: an anterior segment OCT study. Br J Ophthalmol 2008;92:103-7.
57. Schallhorn SC, Farjo AA, Huang D, Boxer Wachler BS, Trattler WB, Tanzer DJ, Majmudar PA, Sugar A. Wavefront-guided LASIK for the correction of primary myopia and astigmatism: a report by the American Academy of Ophthalmology. Ophthalmology 2008;115:115:1249-1261.
58. Alasil T, Tan O, Lu ATH, Huang D, Sadun, AA, Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy. Ophthalmic Surg Laser Imaging 2008;39:S71-9.
59. Ramos JLB, Zhou S, Yo C, Tang M, Huang D, High-resolution imaging of complicated LASIK flap interface fluid syndrome. Ophthalmic Surg Lasers Imaging 2008;39:S80-2.
60. Lu ATH, Wang M, Varma R, Schuman JS, Greenfield DS, Smith SD, Huang D; Advanced Imaging for Glaucoma Study Group. Combining nerve fiber layer parameters to optimize glaucoma diagnosis with optical coherence tomography. Ophthalmology 2008;115:1352-7.
61. Schallhorn JM, Tang M, Li Y, Song JC, Huang D. Optical coherence tomography of clear corneal incisions for cataract surgery. J Cataract Refract Surg 2008;34:1561-5.
62. Lim JI, Tan O, Fawzi AA, Hopkins JJ, Gil-Flamer JH, Huang D, A pilot study of Fourier domain optical coherence tomography of retinal dystrophy patients. Am J Ophthalm, 2008;146:417-426.
63. Li Y, Meisler DM, Tang M, Lu ATH, Thakrar V, Reiser BJ, Huang D, Keratoconus diagnosis with optical coherence tomography pachymetry mapping. Ophthalmology 2008;115:2159-2166.
ARTICLES IN PRESS
64. Memarzadeh F, Tang M, Li Y, Chopra V, Francis BA, Huang D. Optical coherence tomography assessment of angle anatomy changes after cataract surgery. Am J Ophthalmol. in press.
65. Ramos JLB, Li Y, Huang D, Clinical and research applications of anterior segment optical coherence tomography, Clin Exp Ophthalmol 2009.
66. Savini G, Goto E, Carbonelli M, Barboni P, Huang D. Agreement between Stratus and Visante optical coherence tomography systems in tear meniscus measurements. Cornea, in press.
67. Zhou S, Li Y, Lu ATH, Liu P, Tang M, Yiu SC, Huang D, Reproducibility of tear meniscus measurement by Fourier-domain optical coherence tomography: a pilot study. Ophthalmic Surg Lasers Imaging in press.
68. Wang Y, Bower BA, Izatt JA, Tan O, Huang D. Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography. J Biomed Opt in press.
BOOKS
1. Huang D, Kaiser P, Lowder C, Traboulsi E, editors, Retinal Imaging, Elsevier Inc., Philadelphia, 2006.
2. Steinert R, Huang D, editors, Anterior Segment Optical Coherence Tomography, SLACK Inc., Thorofare, NJ, 2008.
BOOK CHAPTERS
1. J.A. Izatt, M.R. Hee, D. Huang, J.G. Fujimoto, E.A. Swanson, C.P. Lin, J.S. Schuman, C.A. Puliafito, “Optical coherence tomography for medical diagnostics,” in Medical Optical Tomography: Functional Imaging and Monitoring , pp. 451-472, Society of Photo-Optical Instrumentation Engineers, Bellington, Washingon (1993).
2. D. Huang, “Physics of Customized Cornea Ablation,” in Customized Corneal Ablation: The Quest for SuperVision, 1st Edition, S. MacRae, R.R. Krueger, R. Applegate, Editors, SLACK, Inc. 2001.
3. M.R. Chalita, D. Huang, Y. Li, S. Radhakrishman, “Tomografia de Coerencia Optica de Cornea e Segmento Anterior” in Cirurgia Refractive, M.R. Alves, W. Chamon, W. Nose, Editors, Cultura Medica 2003.
4. M.R. Chalita, D. Huang, Y. Li, S. Radhakrishman, “Aspectos Basicos da Tomografia de Coerencia Optica de Cornea e Segmento Anterior (CAS OCT)” in Cirurgia Refractiva, M.R. Alves, W. Chamon, W. Nose, Editors, Cultura Medica 2003.
5. D. Huang, “Physics of Customized Cornea Ablation,” in Wavefront Customized Visual Correction: The Quest for SuperVision, 2nd Edition, pp. 171-180. R. R. Krueger, R. A. Applegate, S. M. MacRae, Editors, SLACK, Inc. 2004.
6. D. Huang, Y. Li, S. Radhakrishnan, M.R. Chalita, “Corneal and anterior segment optical coherence tomography,” in Optical Coherence Tomography of Ocular Diseases, 2nd Edition, J.S. Schuman, C.A. Puliafito, J.G. Fujimoto, Editors, SLACK, Inc. 2004.
7. Fujimoto JG, Hee MR, Huang D, Schuman JS, Puliafito CA, Swanson E. Optical coherence tomography: its history, how it works, and what its images show, Everyday OCT: A Handbook for Clinicians and Technicians, Schuman JS, Puliafito CA, Fujimoto JG, Editors, SLACK, Inc. 2006.
8. Huang D,, Izatt JA. Physics and fundamentals of anterior segment optical coherence tomography. in Anterior Segment Optical Coherence Tomography. Steinert RF, Huang D, editors. Thorofare, NJ: SLACK; 2008:1-10.
9. Li Y , Huang D. Keratoconus screening. in Anterior Segment Optical Coherence Tomography. Steinert, RF Huang D, editors. Thorofare, NJ: SLACK; 2008:13-19.
10. Song JC , Huang D. Corneal opacities. in Anterior Segment Optical Coherence Tomography. Steinert RF, Huang D. editors.Thorofare, NJ: SLACK; 2008:53-60.
11. Tang M, Huang D. Intacs intracorneal ring segments. in Anterior Segment Optical Coherence Tomography. Steinert RF, Huang D, editors. Thorofare, NJ: SLACK; 2008:67-74.
12. S. Radhakrishnan, Y. Li, D. Huang. Quantitative measurement of the anterior chamber angle with optical coherence tomography. in Anterior Segment Optical Coherence Tomography. Steinert RF, Huang D, editors. Thorofare, NJ: SLACK; 2008:97-103.
13. Huang D , Izatt, JA, Yasuno Y , de Boer JF. Future direction of anterior segment optical coherence tomography. in Anterior Segment Optical Coherence Tomography. Steinert RF, Huang D. editors. Thorofare, NJ: SLACK; 2008:145-152.
