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Avandia, is a prescription medication used with diet and exercise was created by GlaxoSmithKline to treat type 2 (“adult-onset” or “non-insulin dependent”) diabetes mellitus (“high blood sugar”). Avandia may be used alone or with other anti-diabetic medicines. Active Ingredient: rosiglitazone maleate. When Avandia was first approved it was intended to replace the recalled diabetes drug Rezulin as a safe alternative.