Apostropher.com is a personal blog for the apostropher

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apostropher: doggedly searching for the crux of the biscuit

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People drinking one cup of coffee per day were, on average, 20% less likely to develop alcoholic cirrhosis. For people drinking two or three cups the reduction was 40%, and for those drinking four or more cups of coffee a day the reduction in risk was 80%. Among those who had their blood drawn, liver enzyme levels were higher in individuals who drank more alcohol, indicating liver disease or damage. However, those who drank both alcohol and coffee had lower levels than those who drank alcohol but did not drink coffee.

One of the biggest challenges in treating neurological conditions such as Parkinson's and Alzheimer's disease is finding safe and non-invasive ways to enable drugs to penetrate the brain's natural defense -- the blood-brain barrier. Now scientists have developed a way to temporarily open a very small part of that barrier using focused ultrasound. They hope this precise targeting will allow drugs to enter specific parts of the brain -- without exposing the rest of the brain and without damaging the barrier or surrounding neuronal tissue in the process. [...]

The blood-brain barrier protects the brain, which is why it can be difficult for drugs to penetrate it. The barrier consists of endothelial cells that line the small blood vessels in the brain. These cells are tightly packed to create a wall between most parts of the brain and the rest of the circulatory system, blocking bacteria and all but the smallest molecules.

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